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Low‐dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial
Author(s) -
Souza Leão Kamamoto Cristhine,
Sanudo Adriana,
Hassun Karime M.,
Bagatin Ediléia
Publication year - 2017
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13408
Subject(s) - medicine , seborrheic dermatitis , isotretinoin , dermatology , randomized controlled trial , acne
Background The efficacy of low‐dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies. Objectives This study was designed to determine the efficacy and safety of low‐dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face. Methods A randomized, comparative clinical trial, using two groups, was conducted over 6 months. Patients in Group ISO were treated with isotretinoin 10 mg every other day. In Group X, patients received antiseborrheic topical treatment. Patient opinion, investigator assessment, scalp pruritus, sebum production, and quality of life (QoL) comprised the efficacy outcomes. Results The intention‐to‐treat population comprised a total of 45 patients with mean ± standard deviation ages of 28.7 ± 5.8 years in Group ISO and 29.8 ± 6.5 years in Group X. The rate of sebum production significantly decreased in Group ISO . Patient opinion, investigator, and QoL assessments improved in both groups. Conclusions Low‐dose oral isotretinoin can be a therapeutic modality for moderate to severe seborrhea and seborrheic dermatitis.