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Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis
Author(s) -
Barbosa Natália G.,
Souza Lélia B.,
aka Cassiano F. W.,
Silveira Ericka J. D.
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13365
Subject(s) - medicine , lymphangiogenesis , dysplasia , angiogenesis , epithelial dysplasia , pathology , hypoxia (environmental) , vascular endothelial growth factor , lymphatic system , immunohistochemistry , dermatology , vegf receptors , metastasis , cancer , chemistry , organic chemistry , oxygen
Background Actinic cheilitis is a potentially malignant condition caused mainly by chronic sun exposure. Here we aim to evaluate the role of hypoxia, angiogenesis, and lymphatic density in the clinical and morphological progression of a series of cases of actinic cheilitis. Materials and methods Immunohistochemistry was used to evaluate positivity to hypoxia‐inducible factor ( HIF )‐1 α , vascular endothelial growth factor ( VEGF )‐C, and D2–40 in 40 cases of actinic cheilitis of the lower lip. Results The cases studied exhibited variable degrees of positivity to the markers. The median number of lymphatic vessels was 3.2, 2.4, and 3.0 in lesions showing no epithelial dysplasia ( NED ) and with mild ( MED ) and moderate ( MOED ) epithelial dysplasia, respectively. The median VEGF ‐C positivity index was 82.44% ( NED ), 92.74% ( MED ), and 82.83% ( MOED ), and the median HIF ‐1 α positivity index was 11.57% ( NED ), 5.26% ( MED ), and 13.55% ( MOED ). No significant differences in lymphatic density or median VEGF ‐C and HIF ‐1 α positivity indices were observed between histological grades or clinical presentations of actinic cheilitis ( P > 0.05). Conclusions Although representing early events in lip carcinogenesis, the present results suggest that hypoxia, angiogenesis, and lymphangiogenesis do not influence the morphological or clinical progression of actinic cheilitis.