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Lichen sclerosis: clinicopathological study of 60 cases from Lebanon
Author(s) -
Knio Zeina,
Kurban Mazen,
Abbas Ossama
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13336
Subject(s) - medicine , dermatology , lichen sclerosus , mycosis fungoides , pathology , biopsy , atrophy , sex organ , differential diagnosis , lymphoma , biology , genetics
Abstract Background Lichen sclerosus ( LS ) is an uncommon idiopathic chronic inflammatory debilitating disease with predilection for the genital region. Our recent encounter with an LS case exhibiting perineural inflammation microscopically prompted us to assess the features of all patients diagnosed with LS at our institution. Materials and methods All cases of LS diagnosed between 1990 and 2014 were retrospectively reviewed. Diagnosis was confirmed with demonstration of microscopic features typical of LS. Results Sixty patients (42 women and 18 men) with 65 biopsy specimens of LS were identified, of which 41 were extragenital, 16 genital, and three had both. Histopathologically, significantly higher proportions of follicular plugging, atrophy, and vacuolar interface changes were observed in extragenital LS cases, while angiokeratoma‐like, mycosis fungoides‐like, and pseudoepitheliomatous changes were only seen in genital LS . Perineural inflammation was observed as a novel finding in 22 cases (33.8%) of LS . Conclusion Features of patients with LS in this study are generally comparable to those published in the literature, with some differences. In contrast to the literature, extragenital LS was more frequently encountered. Histopathologically, perineural inflammation was not an uncommon feature of LS and thus may serve as a clue in the differentiation of LS from its mimickers.