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Interventions for molluscum contagiosum in people infected with human immunodeficiency virus: a systematic review
Author(s) -
Martin Paul
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13267
Subject(s) - medicine , molluscum contagiosum , cochrane library , observational study , systematic review , medline , psychological intervention , grey literature , randomized controlled trial , cohort study , family medicine , dermatology , surgery , psychiatry , political science , law
Abstract Background Molluscum contagiosum ( MC ) is a viral skin disease that presents with white, painless papules with central umbilication. In immunocompent individuals, MC is usually a benign infection that resolves without intervention. In HIV positive people, symptoms of MC can be more severe. Objective The aim of this systematic review is to analyze the literature on strategies for treating MC in people concomitantly infected with HIV and subsequently make recommendations on best management strategies for these people. Method Searches were conducted of the following electronic databases: MEDLINE , EMBASE , Cochrane Library, PubMed, LILACS , Ind MED , Global Health, ClinicalTrials.Gov, and Current Controlled Trials. Grey literature was searched via the New York Academy of Medicine Grey Literature Report and Open Grey. References cited in previous reviews and references cited in studies identified as being possibly relevant were also reviewed. No language restrictions were imposed. Papers from 1980 to present were reviewed. Results & Discussion Thirteen studies were included in this review. Two papers were comparative studies, one of which was randomized and neither of which were blinded. Ten papers were observational studies with heterogeneous populations. One study was a multicentre cohort study. Conclusion Given the poor quality of study design, wide array of outcome variables, and lack of objective evidence, no specific recommendation can be made for the treatment of MC in people infected with HIV , other than the initiation of ART . Despite the good impact ART has made on prevalence of dermatologic disease, MC remains an important cause of morbidity in HIV positive populations.