Premium
Tattoo‐induced psoriasis: an umpteenth example of immunocompromised district
Author(s) -
Caccavale Stefano,
Squillace Lorenzo,
Ruocco Eleonora
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13251
Subject(s) - medicine , dermatology , citation , psoriasis , library science , computer science
highest sensitivity, followed by the BP180 ELISA assay in the initial diagnosis of BP. We further evaluated the value of using both tests together and did not find that adding BP180 assay to IIF provided a significant increase in diagnostic sensitivity. Given the high sensitivity and relatively low cost of IIF, physicians may consider performing IIF first in the diagnosis of BP and only perform the ELISA tests when the former turned out to be negative. On the other hand, the same IIF finding of roof-pattern immunoreactant binding can be observed in other immunobullous diseases, such as mucous membrane pemphigoid, and anti-BP180 remain important in ambiguous cases. Anti-BP180 may also be helpful in monitoring disease severity, outcome, and relapse in some BP cases. In pemphigoid gestationis, a variant of BP, anti-BP180 remains a specific diagnostic test and an early predictor of disease later in pregnancy. The study limitations include a small sample size, which might not have enough power to detect any significant difference in the sensitivities. There is also a lack of control group for specificities to be calculated. Our patients with BP were also from an inpatient cohort. In conclusion, IIF, followed by the BP180 test, demonstrated a high rate of diagnostic sensitivity in our cohort of patients with BP. Performing BP180 in addition to IIF did not confer a significant increase in sensitivity. These non-invasive serological tests can serve as useful adjuncts in the diagnosis of suspected cases of BP.