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Lichen planus and dyslipidemia: a systematic review and meta‐analysis of observational studies
Author(s) -
Lai Yi C.,
Yew Yik W.,
Schwartz Robert A.
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13234
Subject(s) - medicine , dyslipidemia , meta analysis , odds ratio , publication bias , cochrane library , confidence interval , funnel plot , observational study , gastroenterology , disease
Background Lichen planus ( LP ) is a chronic inflammatory disease that has been shown to be positively associated with dyslipidemia. However, the magnitude and types of the underlying lipid abnormalities have not been investigated. This study aims to conduct a systematic review and meta‐analysis to investigate the qualitative and quantitative association between LP and dyslipidemia. Methods A systematic search of studies published from inception to April 1, 2015, was conducted using MEDLINE , EMBASE , Web of Science, and Cochrane library databases. Meta‐analyses of observational studies with both categorical and continuous outcome were performed. DerSimonian and Lard random effects models were utilized to calculate the pooled odds ratio and weighted mean difference (WMD). Publication bias was evaluated by funnel plot and Egger's test. Results Seven studies with 5242 subjects were included in this meta‐analysis. Patients with LP were significantly more likely to have dyslipidemia, with a pooled odds ratio of 1.74 (95% confidence interval [CI]: 1.19–2.54, P = 0.004). LP was associated with higher levels of triglycerides (WMD 83.37 mg/dl, 95% CI 0.62–166.12, P = 0.048), low‐density lipoprotein (18.75 mg/dl, 95% CI −17.21 to 54.72, P = 0.307), total cholesterol (19.22 mg/dl, 95% CI −8.80 to 47.25, P = 0.179), and lower levels of high‐density lipoprotein cholesterol (−8.96 mg/dl, 95% CI −21.22 to 3.30, P = 0.152). Conclusions Despite considerable heterogeneity, this study demonstrated that LP was significantly associated with an increased risk of dyslipidemia and higher triglyceride levels. For patients presenting with LP , physicians should be cognizant of this association and consider screening them for dyslipidemia.