Premium
Expression of angiopoietin‐1, angiopoietin‐2, and their receptor Tie2 in verruca vulgaris (common skin warts)
Author(s) -
ElNabarawy Eman A.,
ElHanafy Ghada M.,
Rashed Laila A.,
Yasin Fatma S.
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13191
Subject(s) - angiopoietin receptor , medicine , angiopoietin , angiopoietin 2 , verruca vulgaris , immunology , dermatology , cancer research , angiogenesis , vegf receptors , vascular endothelial growth factor
Abstract Background Angiogenesis and vasodilatation are reported associated with the development of verruca vulgaris, yet vascular endothelial growth factor overexpression was not detected in the lesions of common warts. Angiopoietins, as angiogenesis factors, have not been studied before in warts. Objectives To assess tissue expression of angiopoietin 1 (Ang1), angiopoietin 2 (Ang2), and their receptor Tie2 in the lesions of common warts to try to identify their role as pro‐angiogenic factors in the development of these lesions. Patients and methods Fifty patients with common skin warts and 50 age‐ and sex‐matched controls were included in this study. Four millimeter punch skin biopsies were taken from warts and from normal skin of controls for the detection of gene expression of Ang1, Ang2, and Tie2 using real‐time polymerase chain reaction. Results The mean levels of Ang1, Ang2, and Tie2 were significantly higher in the lesions of common warts compared to the normal skin of controls ( P < 0.001 for all). Conclusions Upregulation of Ang1, Ang2, and Tie2 seems to play a possible role in the angiogenesis associated with common skin warts.