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Expression of vascular endothelial growth factor and other cytokines in atopic dermatitis, and correlation with clinical features
Author(s) -
Samochocki Zbigniew,
Bogaczewicz Jarosław,
SysaJędrzejowska Anna,
McCauliffe Daniel P.,
Kontny Ewa,
Wozniacka Anna
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13132
Subject(s) - scorad , medicine , vascular endothelial growth factor , atopic dermatitis , cytokine , pathogenesis , interleukin 6 , tumor necrosis factor alpha , vegf receptors , immunology , disease , dermatology life quality index
Background Vascular endothelial growth factor ( VEGF ) was found increased in the stratum corneum of patients with atopic dermatitis ( AD ). However, its potential pathogenic role(s) in AD needs further clarification. Objective The aim of this study was to determine whether VEGF serum levels correlate with other selected cytokine levels and features of AD . Methods VEGF and other cytokine levels were measured in 83 patients with AD and in a control group and then correlated with clinical and laboratory parameters of AD . Results The mean serum concentrations of VEGF and tumor necrosis factor α were significantly higher in patients with AD than in the control group, whereas the mean interleukin eight serum level was lower. VEGF concentrations correlated with the severity of AD as expressed by SCORAD index and objective SCORAD . Conclusion VEGF could be regarded as a potentially important mediator in the pathogenesis of AD , as VEGF levels correlate somewhat with AD severity.