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Efficacy of magnesium chloride in the treatment of Hailey–Hailey disease: some further considerations
Author(s) -
Borghi Alessandro,
Rimessi Alessandro,
Minghetti Sara,
Corazza Monica,
Pinton Paolo,
Virgili Annarosa
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.13096
Subject(s) - medicine , humanities , art
Based on our clinical observation and experimental results, it can be hypothesized that MgCl2 could act as an inhibitor of the Ca2+-extruding activity in keratinocytes favoring intracellular Ca2+-disponibility and Ca2+-dependent mechanisms in desmosome assembly. This may represent the molecular basis of the treatment of Hailey-Hailey disease with MgCl2 solution
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