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An open‐label, single‐arm trial of the safety and efficacy of a novel preparation of glutathione as a skin‐lightening agent in F ilipino women
Author(s) -
Handog Evangeline B.,
Datuin Maria Suzanne L.,
Singzon Ivan A.
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12999
Subject(s) - glutathione , medicine , lozenge , buccal administration , oral administration , gastrointestinal tract , adverse effect , thiol , buccal mucosa , pharmacology , physiology , dermatology , surgery , gastroenterology , oral cavity , biochemistry , dentistry , chemistry , archaeology , history , enzyme
Background Glutathione ( GSH ) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less successful in elevating plasma GSH levels. Objectives The use of a lozenge containing GSH was investigated in order to evaluate the buccal mucosa as a route for GSH administration. Substances that are absorbed through the buccal route go directly into the systemic circulation, effectively bypassing the gastrointestinal tract. Methods Thirty Filipino females with Fitzpatrick skin types IV or V received a glutathione‐containing lozenge daily for eight weeks. Results Findings showed a significant decrease in melanin indices from baseline to endpoint that became evident in as little as two weeks. There were no serious adverse events, and laboratory examination findings remained normal. Conclusions The authors conclude that the lozenge containing glutathione was safe and effective in lightening the skin of Filipino women.