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Correlation of human papillomavirus types with clinical features of patients with condyloma acuminatum in China
Author(s) -
Cong Xianling,
Sun Ran,
Zhang Xuewen,
Wang Yuqian,
Wang Liying,
Yu Yongli
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12964
Subject(s) - medicine , hpv infection , human papillomavirus , polymerase chain reaction , condyloma acuminatum , disease , typing , papillomaviridae , correlation , genital warts , pathological , vaccination , virology , gene , cancer , microbiology and biotechnology , biology , cervical cancer , biochemistry , geometry , mathematics
Background Condyloma acuminatum ( CA )‐related human papillomavirus ( HPV ) typing has focused on the prevalence of HPV types. The correlation between HPV types and the clinical features of CA has rarely been documented. Aims The purpose of this study was to investigate the relationship between HPV types and the clinical features of CA . Methods Polymerase chain reaction–restriction fragment length polymorphism was used to type HPV in the CA lesions from 80 Chinese patients with full clinical data. Results We determined that HPV 6 and HPV 11 single infections were the most frequent and accounted for 38.7 and 36.3%, respectively. Multiple infections caused by HPV 6, HPV 11, HPV 16, HPV 18, and/or HPV 31 accounted for the remaining 25%. We were the first to document the HPV 11 and HPV 31 co‐infection in a patient with colon carcinoma infected anal CA in China. The statistical analysis demonstrated that multiple HPV infections predisposed an individual to more warts, larger warts, a longer disease course, and a greater frequency of recurrence. The cases infected with the high‐risk type, HPV 16, accounted for 60% of the multiple infections and had a higher relapse rate than any other type of HPV infection. Conclusions Compared with a single HPV type infection, multiple HPV infections in CA were related to a more severe disease and a worse prognosis. These data provide useful information for the treatment and prognosis of CA . Mapping the proportion of CA caused by the virus types pre‐vaccination enables the prediction of the vaccination benefits regarding CA burden reduction.