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Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta‐analysis
Author(s) -
Chamani Goli,
Rad Maryam,
Zarei Mohammad Reza,
Lotfi Sodabeh,
Sadeghi Masoumeh,
Ahmadi Zahra
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12925
Subject(s) - tacrolimus , pimecrolimus , medicine , oral lichen planus , dermatology , meta analysis , clobetasol propionate , placebo , pathology , psoriasis , alternative medicine , transplantation
Summary This study was carried out to assess and compare the efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus ( OLP ). The Cochrane Central Register of Controlled Trials, PubMed, Scopus, Science Direct, Springer Journals, and Elsevier databases were searched using specific keywords relevant to the research question for articles published from 1998 to December 31, 2012. Finally, 15 articles that assessed the effects of tacrolimus, clobetasol, and pimecrolimus on improvements in OLP were reviewed. In addition, a meta‐analysis of odds ratios ( OR s) was carried out for data in 10 of the 15 articles. The results showed that the OR s for improvements in OLP in patients taking clobetasol or tacrolimus, compared with those taking placebo or other drugs, were 1.19 and 8.00, respectively. It appears that topical tacrolimus is an effective alternative to topical clobetasol and may be considered as a first‐line therapy in the management of OLP .