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T‐helper 22 cells as a new player in chronic inflammatory skin disorders
Author(s) -
Mirshafiey Abbas,
Simhag Anita,
El Rouby Nadia M. M.,
Azizi Gholamreza
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12883
Subject(s) - immunology , medicine , interleukin 22 , t helper cell , psoriasis , cytokine , c c chemokine receptor type 6 , chemokine receptor , chemokine , interleukin 17 , tumor necrosis factor alpha , t cell , interleukin , inflammation , immune system
T‐helper 22 (Th22) cell is a new subset of CD 4 + T cells that secrets interleukin ( IL )‐22 but not IL ‐17 or interferon‐ γ . Th22 is distinct from Th17 and other known CD 4 + T‐cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR 6 + CCR 4 + CCR 10 + phenotype and aryl hydrocarbon receptor as the key transcription factor. This T‐helper subset, by producing cytokines such as IL ‐22, IL ‐13, and tumor necrosis factor‐ α , is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL ‐22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis.