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Role of the tumor necrosis factor family member LIGHT in the pathogenesis of atopic dermatitis
Author(s) -
Seifeldin Neveen Salah,
El Sayed Shereen Bendary,
Asaad Marwa Kamal,
Aly Alaa Ahmed
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12851
Subject(s) - medicine , scorad , pathogenesis , atopic dermatitis , eosinophil , immunology , herpes simplex virus , tumor necrosis factor alpha , gastroenterology , virus , dermatology life quality index , asthma , psoriasis
Background LIGHT (the name of which is derived from “homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for herpes simplex virus entry mediator, and expressed by T lymphocytes”), is a member of the tumor necrosis factor superfamily that is involved in various inflammatory diseases. Objectives To assess serum LIGHT levels in patients with atopic dermatitis ( AD ) before and after treatment and compare it with controls. To correlate serum LIGHT with the severity scoring of AD ( SCORAD ) index. Another objective is to compare LIGHT levels between lesional skin in patients with AD and controls. Methods Twenty patients with AD and 20 healthy controls were enrolled in the study. Serum LIGHT levels were examined using an enzyme immunoassay technique. Serum total IgE levels, absolute eosinophil count, and eosinophil percentage were also done for both patients and controls. The SCORAD index was done for every patient before and after treatment. Skin LIGHT levels were analyzed using enzyme‐linked immunosorbent assay kit and compared with control skin. Results Serum LIGHT levels in patients with AD were significantly higher than that of healthy controls and correlated positively with SCORAD index. LIGHT concentrations decreased as the symptoms were improved by treatment. A significant correlation was found on comparing the LIGHT serum levels and other established markers of disease severity. LIGHT levels in lesional skin in these patients were markedly higher than LIGHT levels in normal skin. Conclusion LIGHT may play an important role in the pathogenesis of AD . This may presumably have possible future implications on the treatment of this chronic disease.