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Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study
Author(s) -
Bülbül Şen Bilge,
Ekiz Özlem,
Rifaioğlu Emine Nur,
Büyükkaya Eyüp,
Karakaş Mehmet Fatih,
Büyükkaya Şule,
Bilen Perihan,
Akçay Adnan Burak,
Kurt Mustafa,
Şen Nihat
Publication year - 2016
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12703
Subject(s) - medicine , psoriasis , ejection fraction , cardiology , speckle tracking echocardiography , subclinical infection , population , diastole , blood pressure , heart failure , environmental health , dermatology
Abstract Background Psoriasis is a systemic inflammatory disease and is reportedly associated with adverse cardiovascular risks. Left ventricular ( LV ) function has not been studied comprehensively in psoriasis. Objectives This study was conducted to study LV mechanics in patients with psoriasis by speckle tracking echocardiography. Methods The study population consisted of 40 patients with psoriasis and 35 age‐ and sex‐matched control subjects. Two‐dimensional echocardiography images were obtained from LV apical four‐chamber (4 C ), long axis ( LAX ), and two‐chamber (2 C ) views. Peak longitudinal strain and strain rate were obtained from 4 C , LAX , and 2 C views. Global strain and strain rate were calculated by averaging data for the three apical views. Results Patients with psoriasis had significantly lower mean ± standard deviation ( SD ) 4 C (17.1 ± 1.7 vs. 19.2 ± 2.3; P < 0.01), LAX (16.6 ± 1.5 vs. 19.5 ± 2.3; P < 0.01), and 2 C (16.5 ± 1.5 vs. 19.4 ± 2.2; P < 0.01) peak longitudinal strain values compared with the control group. Moreover, mean ± SD LV global strain (16.6 ± 1.5 vs. 19.9 ± 2.1; P < 0.01) and strain rate (1.39 ± 0.30 vs. 1.51 ± 0.20; P < 0.01) values were found to be significantly lower in the psoriasis group. In a multiple regression model, global strain was independently associated with high‐sensitivity C ‐reactive protein ( β = 0.29, P = 0.04), duration of disease ( β = 0.35, P < 0.01), ejection fraction ( EF ) ( β = 0.38, P =0.01), and the ratio of early diastolic mitral inflow velocity to early diastolic annular velocity ( E / E ′ ratio) ( β = 0.34, P =0.02). Also, in a multiple regression model, global strain rate was independently associated with duration of disease ( β = 0.36, P < 0.01), EF ( β = 0.32, P = 0.01), and E / E ′ ratio ( β = 0.35, P < 0.01). Conclusions Using 2‐ D strain imaging, we have demonstrated that patients with psoriasis have lower LV functions.