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HIPK 2 expression in progression of cutaneous epithelial neoplasm
Author(s) -
Kwon Mi Jung,
Min Soo Kee,
Seo Jinwon,
Kim Dong Hoon,
Sung Chang Ohk,
Lim Man Sup,
Cho Jiwoong,
Park HyeRim
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12664
Subject(s) - keratoacanthoma , actinic keratosis , carcinogenesis , immunohistochemistry , basal cell carcinoma , medicine , cancer research , tumor progression , pathology , bowen's disease , carcinoma , cancer , basal cell
Background Homeodomain‐interacting protein kinase 2 ( HIPK 2) is responsible for a DNA damage response, centrally regulating p53. The aberrant HIPK 2 expression is known to be involved in carcinogenesis in several malignancies. However, the correlation of HIPK 2 expression along with progression of cutaneous epithelial neoplasm has not been investigated. Methods Using immunohistochemistry and real‐time reverse transcription–polymerase chain reaction, we examined the correlation between HIPK 2 and HIPK 2‐related protein expressions and the progression of some cutaneous epithelial neoplasms (i.e., actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma, and basal cell carcinoma). Results HIPK2 expression was distinct between preinvasive and invasive lesions: the expression decreased in keratoacanthoma (none of eight) and squamous cell carcinoma (five of 35) compared to actinic keratosis (12 of 19) and Bowen's disease (10 of 23) ( P < 0.001). HIPK2 expression was also negatively correlated with aggressiveness of basal cell carcinoma; high‐risk subtypes showed lower HIPK2 expression than did low‐risk subtypes ( P < 0.001). HIPK2 mRNA expression of each tumor group was significantly higher than that of normal skin. HIPK2 mRNA expression of each tumor group was not correlated with the relevant HIPK2 protein expression, which was consistent with previous studies. Conclusions HIPK 2 expression tends to be decreased along tumor progression and may be involved with the invasive potential, suggesting a possible tumor suppressor role for HIPK 2.