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Toxic epidermal necrolysis induced by methazolamide in a C hinese– K orean man carrying HLA ‐ B *59:01
Author(s) -
Shu Chang,
Shu Dan,
Tie Duerna,
Yu Mengqing,
Zhang Rui,
Wang Tong,
Dong Qi,
Sun Qiuning,
Mao Xuming,
Yan Yan
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12651
Subject(s) - medicine , toxic epidermal necrolysis , genotype , human leukocyte antigen , polymerase chain reaction , hla dq , immunology , allele , hla b , gastroenterology , dermatology , genetics , haplotype , antigen , biology , gene
Background Methazolamide is used to lower intraocular pressure in patients with glaucoma. S tevens– J ohnson syndrome ( SJS ) and toxic epidermal necrolysis ( TEN ) associated with methazolamide treatment have been diagnosed in K orean, J apanese, and J apanese‐ A merican patients. According to recent research, the human leukocyte antigen ( HLA ) allele HLA ‐B*59:01 is strongly linked to SJS / TEN associated with methazolamide treatment. Objective A patient of C hinese– K orean ethnicity was diagnosed with TEN associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease. Methods A polymerase chain reaction sequence‐specific primer ( PCR ‐ SSP ) typing system was used to genotype this patient's peripheral blood DNA for HLA ‐ B *59 . Results The genotype HLA ‐ B *59:01 was detected in the patient. Conclusions This study demonstrates the genotype of HLA ‐ B *59:01 in a patient with TEN associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide‐associated SJS / TEN .