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Association of HLA ‐B*1502 allele with lamotrigine‐induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta‐analysis
Author(s) -
Zeng Tao,
Long YueSheng,
Min FuLi,
Liao WeiPing,
Shi YiWu
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12570
Subject(s) - lamotrigine , toxic epidermal necrolysis , medicine , odds ratio , meta analysis , allele , cochrane library , human leukocyte antigen , dermatology , immunology , psychiatry , genetics , antigen , biology , epilepsy , gene
Background Despite several studies investigating the association between the human leukocyte antigen HLA ‐B*1502 allele and lamotrigine‐induced Stevens–Johnson syndrome ( SJS ) and toxic epidermal necrolysis ( TEN ) in Han Chinese subjects, the relationship remains unclear. Objectives We performed a systematic review and meta‐analysis to ascertain the association between the HLA ‐B*1502 allele and lamotrigine‐induced SJS and TEN in Han Chinese populations. Methods We searched the biomedical literature archived in the MEDLINE , Cochrane Library, EMBASE , Chinese Biomedical, Chinese National Knowledge Infrastructure, and China Science and Technology Journal databases. Only studies investigating the association between HLA ‐B*1502 and lamotrigine‐induced SJS / TEN were included. We then performed a meta‐analysis of the data in these studies. Results Four studies including a total of 12 patients with SJS / TEN and 128 lamotrigine‐tolerant control subjects were identified. The HLA ‐B*1502 allele was present in 33.3% (four of 12) of lamotrigine‐induced SJS / TEN cases but in only 9.4% (12 of 128) of lamotrigine‐tolerant controls. The occurrence of SJS / TEN was thus associated with the presence of the HLA ‐B*1502 allele (odds ratio: 4.98, 95% confidence interval 1.43–17.28; P < 0.05). Conclusions We found a statistical association between HLA ‐B*1502 and lamotrigine‐induced SJS / TEN in Han Chinese subjects. Future studies with larger sample sizes are suggested to verify the results.