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Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends
Author(s) -
Kallini Joseph R.,
Hamed Nouran,
Khachemoune Amor
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12553
Subject(s) - medicine , cryosurgery , skin cancer , curettage , dermatology , melanoma , biopsy , carcinoma , radiation therapy , basal cell , mohs surgery , cancer , surgery , pathology , cancer research
Squamous cell carcinoma ( SCC ) is the second most common non‐melanoma skin cancer. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). We describe the salient features of cutaneous SCC . We also review novel classification schemes proposed during the last decade which attempt to stratify SCC lesions based on prognosis. Biopsy leads to definitive diagnosis. Treatment includes surgical excision; Mohs micrographic surgery produces excellent cure rates and spares the maximal amount of tissue. Other modalities include electrodessication and curettage, cryosurgery, radiotherapy, topical medications, photodynamic therapy, and systemic therapy. Management and follow‐up depend on the risk stratification of individual lesions.