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Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family
Author(s) -
Akoğlu Gülşen,
Metin Ahmet,
Ceylan Gülay Güleç,
Emre Selma,
Akpolat Demet,
Süngü Nuran
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12538
Subject(s) - human leukocyte antigen , polymerase chain reaction , allele , koilocyte , medicine , pathogenesis , antigen , typing , immunology , pathology , biology , gene , genetics , cancer , cervical intraepithelial neoplasia , cervical cancer
Background Focal epithelial hyperplasia ( FEH ) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus ( HPV ) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system ( HLA ). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types. Methods HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction. Results Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV 13 was detected by polymerase chain reaction. HLA DQA 1*0501, HLA DQB 1*0302, and HLA DRB 1*11 alleles were common in all family members. HLA DRB 1*04 was detected in three of them. Conclusion This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH .