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Different effect of oral cyclosporine therapy and oral antihistamine therapy on serum high‐sensitivity C ‐reactive protein level and thymus and activation‐regulated chemokine level in atopic dermatitis in older children and adulthood
Author(s) -
Ohtsuka Tsutomu
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12374
Subject(s) - antihistamine , medicine , atopic dermatitis , gastroenterology , combination therapy , c reactive protein , chemokine , immunology , inflammation
Background Many patients with atopic dermatitis ( AD ) are treated with oral cyclosporine or antihistamine therapy in clinical practice. Objective To evaluate the effectiveness of oral cyclosporine and antihistamine therapy on clinical and laboratory findings in patients with AD . Subjects and methods Twenty‐five patients with AD (male–female = 11 : 14, age 16–42 years old, mean 26.2 years old) were treated with oral cyclosporine therapy. Twenty‐three patients with AD (male–female = 10 : 13, age 15–32 years old, mean 24.2 years old) were treated with oral antihistamine therapy. Laboratory findings including high‐sensitivity C ‐reactive protein ( CRP ) and thymus and activation‐regulated chemokine ( TARC ) were statistically studied. Results Serum TARC level after oral cyclosporine therapy (1013 ± 883 pg/ml) was significantly decreased compared to before therapy (38 194 ± 4678 pg/ml; P < 0.02). Basophil counts in peripheral blood after the therapy (49.7 ± 26.4 × 10 −3 cells/μl) were more significantly increased than before therapy (41.1 ± 16.7 × 10 −3 cells/μl; P < 0.05). Serum high‐sensitivity CRP level after antihistamine therapy (0.09 ± 0.08 mg/ml) was significantly decreased compared to before therapy (0.13 ± 0.12 mg/ml; P < 0.05). Basophil counts in peripheral blood after the therapy (33.4 ± 16.2 × 10 −3 cells/μl) were more significantly decreased than before therapy (41.5 ± 23.3 × 10 −3 cells/μl; P < 0.01). Conclusion Different effects of oral cyclosporine therapy and oral antihistamine therapy to serum high‐sensitivity CRP level, TARC level, and peripheral blood basophils in adult patients with AD were shown. A combination of these two therapies may be more effective for the treatment of AD in adults.