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Outcome of patients with serology suggestive of past hepatitis B virus infection during antitumor necrosis factor therapy for psoriasis
Author(s) -
Navarro Raquel,
ConchaGarzón María José,
Castaño Carlos,
Casal Cristina,
Guiu Alba,
Daudén Esteban
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12313
Subject(s) - medicine , hbsag , etanercept , adalimumab , infliximab , serology , immunology , psoriasis , hepatitis b virus , hepatitis b , gastroenterology , tumor necrosis factor alpha , virus , antibody
Background Recently, the reactivation during treatment with tumor necrosis factor ( TNF ) blockers has exceptionally been described in patients with hepatitis B virus ( HBV ) antigen‐negative ( HB sAg). The objective was to evaluate the influence of anti‐ TNF agents in patients with psoriasis and serology suggesting past hepatitis B state. Methods The inclusion criteria were chronic plaque psoriasis treated with anti‐ TNF therapy, HB sAg‐negative, and HB cAb‐positive. We gathered the demographic data and type and duration of anti‐ TNF agent. Serum aminotransferase levels and HBV serologic status were requested at baseline and during follow‐up. Results We have included 13 patients (four women, nine men) (mean age of 62.1 years). The agent was etanercept in seven cases, infliximab in four patients, and adalimumab in the other two. The mean duration of TNF therapy was 28.6 months. None of them became HB sAg‐positive. Neither signs nor symptoms of acute hepatitis were reported. Conclusion The management of HB sAg‐negative patients is unresolved. Only nine cases of HBV reactivation during treatment with TNF blockers have been reported. Despite the low risk of reactivation in these patients, we recommend the monitoring of serum aminotransferase levels, HB sAb titers, HB sAg and, if possible, viral load.