Premium
Left ventricular systolic asynchrony: an important sign for cardiac involvement in plaque‐type psoriasis
Author(s) -
Örem Cihan,
Kazaz Zeynep,
Yaylı Savaş,
Çevik Osman Çağlar,
Kırış Abdulkadir,
Öztürk Mustafa,
Arslan Bilgihan,
Örem Asım
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12276
Subject(s) - medicine , cardiology , psoriasis , basal (medicine) , asynchrony (computer programming) , ejection fraction , doppler imaging , systole , blood pressure , diastole , heart failure , dermatology , computer network , asynchronous communication , computer science , insulin
Psoriasis is associated with cardiovascular diseases ( CVD ). The purpose of this study was to evaluate the relationship between Left Ventricular ( LV ) asynchrony and psoriasis. Asynchrony was assessed in 31 patients with psoriasis without evidence of CVD and 25 healthy subjects. All the patients and controls were subjected to tissue synchronization imaging ( TSI ), and conventional and tissue Doppler echocardiography. The time to regional peak systolic tissue velocity ( T s) in LV by the six‐basal‐six‐midsegmental model was measured on ejection phase TSI images, and four TSI parameters of systolic asynchrony were computed. C ‐reactive protein ( CRP ) and erythrocyte sedimentation rate ( ESR ) levels in psoriatic patients were measured. All TSI parameters of LV asynchrony increased in psoriatic patients compared to the controls: the standard deviation (SD) of the 12 LV segments Ts (37.3 ± 14.8 vs. 24.6 ± 11.1, P = 0.002); the maximal difference in T s between any two of the 12 LV segments (112.7 ± 39.8 vs. 83.1 ± 38.1, P = 0.01), the SD of the six basal LV segments (36.2 ± 17.3 vs. 23.2 ± 14.5, P = 0.008); and the maximal difference in Ts between any two of the six basal LV segments (91.3 ± 43.5 vs. 60.5 ± 37.3, P = 0.01). LV asynchrony was observed in 67.7% of psoriatic patients. Higher CRP (1.9 ± 1.3 vs. 0.92 ± 1.4, P = 0.04) and ESR (34.8 ± 17.3 vs. 20 ± 15.3, P = 0.03) levels were determined in patients with LV asynchrony. Regression analysis showed LV systolic asynchrony ( P = 0.02), Tei index ( P = 0.03), EF ( P = 0.04), and E/A ratio ( P = 0.04) were independently associated with psoriasis. LV asynchrony firstly described in patients with psoriasis may be an important finding of cardiac involvement in psoriasis.