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Genetic endowment of proinflammatory cytokine tumor necrosis factor‐α (–) 308 G > A polymorphism to P arthenium hysterophorus‐ induced airborne contact dermatitis in an I ndian cohort
Author(s) -
Khatri Rakesh,
Akhtar Nasim,
Mukhopadhyay Kasturi,
Verma Kaushal K.,
Sethuraman Gomathy,
Sharma Alpana
Publication year - 2015
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12255
Subject(s) - parthenium , proinflammatory cytokine , medicine , immunology , parthenium hysterophorus , tumor necrosis factor alpha , atopic dermatitis , single nucleotide polymorphism , pathogenesis , allergic contact dermatitis , cytokine , allergy , inflammation , genotype , biology , genetics , gene , agronomy , weed
Background Parthenium dermatitis is a common airborne allergic health problem that induces a cell‐mediated hypersensitivity immune response involving activated T lymphocytes, which culminates in injury to the skin. The disease is manifested as itchy erythematous papules and plaques and primarily affects the exposed areas and flexures. This study aimed to identify the role of tumor necrosis factor ( TNF )‐α (−) 308 G>A polymorphism in the pathogenesis of parthenium dermatitis. Materials and methods A total of 120 subjects, including 60 patients exclusively diagnosed for parthenium dermatitis and 60 healthy individuals, were included in the study. The genotyping of the TNF ‐α (−) 308 G>A region was carried out by the amplification refractory mutational system. Results In the present study, we demonstrated that polymorphism of the TNF ‐α (–) 308 position (A and/or G) was not statistically significant, and there was no difference in the distribution of any alleles of this locus in cases and controls. Conclusion The present study suggests that there is a lack of association of potent proinflammatory cytokine TNF ‐α (−) 308 G>A polymorphism in parthenium dermatitis in the Indian cohort. It interprets genetically endowed transcriptional capacity due to this particular single nucleotide polymorphism but does not support the prevalence of high serum levels of TNF ‐α in parthenium‐induced skin allergic inflammation.