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Polymorphisms in HLA ‐related genes and psoriasis heredity in patients with psoriasis
Author(s) -
Vasku Anna,
BienertovaVasku Julie,
IzakovicovaHolla Lydie,
Pavkova Goldbergova Monika,
Kozacikova Zuzana,
Splichal Zbynek,
Vasku Vladimir
Publication year - 2013
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12213
Subject(s) - psoriasis , haplotype , genotype , medicine , gene polymorphism , family history , immunology , allele , genetics , biology , gene
Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [ TAP 1; TAP 1 333 a/b, TAP 1 637 c/d], the HLA ‐ DRB 1*1501‐rs3135388, tumor necrosis factor [ TNF ]α [−238 G / A ] and N co I TNF β) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 C zech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP 1, TNF α, and TNF β genes (6p21.3) using the polymerase chain reaction‐restriction fragment length polymorphism‐based methodology. Results We observed significantly higher prevalence of I le333 I le TAP 1 allele in patients whose first‐degree relatives had a positive family history of psoriasis ( P a = 0.04). No differences related to family history of psoriasis were observed in HLA ‐ DRB 1*1501 polymorphism. As for the TNF α (−238 G / A ) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second‐ and third‐degree relatives with psoriasis ( P g = 0.008). Similarly, the B 2 B 2 genotype of N co I TNF β polymorphism was more frequent in psoriatic patients, especially women, whose second‐ and third‐degree relatives had psoriasis ( P g = 0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bc CB 1 A was different between not only men and women with psoriasis ( P = 0.007) but also between men and women without a family history of psoriasis ( P = 0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.