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Lymphoma‐associated skin cancer: incidence, natural history, and clinical management
Author(s) -
Brewer Jerry D.,
Habermann Thomas M.,
Shanafelt Tait D.
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12208
Subject(s) - medicine , skin cancer , merkel cell carcinoma , basal cell carcinoma , immunosuppression , lymphoma , malignancy , cancer , chronic lymphocytic leukemia , dermatology , melanoma , leukemia , oncology , metastasis , carcinoma , basal cell , cancer research
The link between immunosuppression and skin cancer has been well described. The two most common situations involving immunosuppression‐associated skin cancer are solid organ transplantation and non‐Hodgkin lymphoma ( NHL ), including chronic lymphocytic leukemia ( CLL ). Patients with lymphoma are more likely to have development of a secondary malignancy, with skin cancer being the most common. The most common types of skin cancer in patients with NHL / CLL include melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Many skin cancers demonstrate increased aggressiveness in patients with NHL / CLL and are associated with higher recurrence rates, increased regional metastasis, and death secondary to skin cancer metastases. This review delineates the current research regarding the relationship between NHL / CLL and cutaneous malignancy. Immunosuppressed patients with skin cancer should be treated promptly and aggressively to decrease recurrence and metastases. Regular skin self‐examinations, dermatologic examinations, sun‐protective habits, and education may prove beneficial in this high‐risk patient population.