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Assessment of left ventricular dyssynchrony in patients with psoriasis
Author(s) -
Bulbul Sen Bilge,
Rifaioglu Emine Nur,
Ekiz Ozlem,
Buyukkaya Eyup,
Kurt Mustafa,
Karakas Mehmet Fatih,
Buyukkaya Sule,
Bilen Perihan,
Akcay Adnan Burak,
Sen Nihat
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12192
Subject(s) - psoriasis , medicine , cardiology , ejection fraction , qrs complex , basal (medicine) , isovolumetric contraction , diastole , heart failure , blood pressure , dermatology , insulin
Background Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular ( CV ) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular ( LV ) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction. Methods Fifty patients with psoriasis and 50 age‐ and sex‐matched control subjects were included in the study. LV dyssynchrony was investigated by color‐coded tissue D oppler imaging. Results In the psoriasis group, the mean high‐sensitive C ‐reactive protein values were significantly higher compared with the controls. Peak A velocity, deceleration time, isovolumetric relaxation time, and E / E ′ values were higher in the psoriasis group; however, E / A ratio and average Em were higher in the control group. LV systolic dyssynchrony parameters [including standard deviation of Ts of the 12 LV segments ( T s‐ SD ‐12), maximal difference in T s between any two of the 12 LV segments, standard deviation of T s of the six basal LV segments, and maximal difference in T s between any two of the six basal LV segments] were found to be higher in the psoriasis group. The patients with ventricular dyssynchrony (a T s‐ SD ‐12 >34.4 ms) were higher in the psoriasis group than the control group (34% vs. 6%, P < 0.01). Conclusion In patients with psoriasis with normal ejection fractions and narrow QRS , LV systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction.