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Tranexamic acid accelerates skin barrier recovery and upregulates occludin in damaged skin
Author(s) -
Yuan Chao,
Wang XueMin,
Yang LiJie,
Wu PeiLan
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12099
Subject(s) - occludin , downregulation and upregulation , tranexamic acid , tight junction , medicine , human skin , skin barrier , dermatology , surgery , biochemistry , chemistry , biology , blood loss , genetics , gene
Background Tranexamic acid ( TA ) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become the topic of a lot of research. The aim of this study is to determine whether TA could repair the skin barrier by means of tight intercellular junctions. Methods Two kinds of damaged skin models were set up and subjected to repeated application of sodium lauryl sulfate and irradiation of ultraviolet B . Through bioengineering technology and immunohistochemistry tests, TA ‐induced changes in skin were detected. Results After 1, 3, 7, and 14 days of application, TA can significantly accelerate barrier recovery and decrease the melanin index values of ultraviolet B irritation skin. The mean optic density of occludin from TA treatment is higher than from self‐repair. Conclusion These experiments suggest that TA can accelerate skin barrier recovery and upregulate occludin induced by physicochemical damages of human skin, but it is advisable to perform more research on the upregulation of occludin in molecular mechanism in the future.