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An unusual co‐occurrence of Langerhans cell histiocytosis and Rosai–Dorfman disease: report of a case and review of the literature
Author(s) -
CohenBarak Eran,
Rozenman Dganit,
Schafer Jan,
Krausz Judith,
DodiukGad Roni,
Gabriel Hertzel,
ShaniAdir Ayelet
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/ijd.12051
Subject(s) - langerhans cell histiocytosis , medicine , rosai–dorfman disease , histiocyte , histiocytosis , langerhans cell , dermatology , pathology , vinblastine , prednisone , asymptomatic , biopsy , pathological , disease , sinus histiocytosis with massive lymphadenopathy , scalp , chemotherapy , surgery , immunology , antigen
Background The co‐occurrence of Langerhans cell histiocytosis ( LCH ; disorder characterized by proliferation of Langerhans cells) and Rosai–Dorfman disease ( RDD ; histiocytic entity that is one of the non‐Langerhans cell diseases) is extremely rare and raises several questions regarding the nature of the diseases. Methods We describe a 10‐year‐old boy who presented with a 3‐month history of right scalp swelling. Clinical, pathological, and imaging evaluation disclosed multiple LCH of bone and cutaneous RDD . Results After initiating prednisone and vinblastine therapy, the patient developed an asymptomatic diffuse papular eruption. Biopsy revealed cutaneous RDD . Treatment was continued with a good response of bone LCH and significant amelioration of the cutaneous findings. Conclusions Co‐occurrence of LCH and RDD is a rare phenomenon. Various explanations, including the role of chemotherapy, are suggested based on our and several previously reported cases.