Open AccessThe role of the multi‐inflammatory index as a novel inflammation‐related index in the differential diagnosis of massive and non‐massive pulmonary embolism
Author(s) -
Boyuk Ferit
Publication year - 2021
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.14966
Subject(s) - medicine , pulmonary embolism , gastroenterology , correlation , lymphocyte , inflammation , cardiology , mathematics , geometry
Objective Systemic inflammatory response and pro‐coagulator factors are critical in acute pulmonary embolism. Recently, there is increasing evidence that the multi‐inflammatory index (MII) may be prognostic in many clinical situations. The study investigated whether MII‐1 and MII‐2 can distinguish massive (MPE) and non‐massive pulmonary embolism (NMPE). Methods A total of 146 patients (73 MPE and 73 NMPE) were included in the study that was designed as a retrospective cross‐sectional analysis. Following haemogram analysis, MII‐1 (platelet‐to‐lymphocyte x CRP) and MII‐2 (neutrophil‐to‐lymphocyte x CRP) were calculated manually. Results MII‐1 and 2 showed a positive significant correlation with PLR and NLR, moderate positive correlation with CPR, and weak positive correlation with PAP ( P < .001). CRP, MII‐1, MII‐2, PAP and systolic BP variables showed strong diagnostic value in distinguishing MPE and NMPE [AUC (SE): 0.816 (0.037), 0.811 (0.038), 0.810 (0.037), 0.870 (0.032) and 0.864 (0.032); respectively] ( P < .001). MPR, MPV, RDW, and PLR in distinguishing MPE and NMPE groups did not show significance ( P > .05). Conclusion Although MII‐1 and MII‐2 are simple, cheap, and easy indexes to calculate, they showed a strong ability to distinguish MPE and NMPE compared with the previously studied classical inflammatory indexes.