Open AccessOmega 3‐rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo‐controlled clinical trial
Author(s) -
Musazadeh Vali,
Dehghan Parvin,
SalehGhadimi Sevda,
Abbasalizad Farhangi Mahdieh
Publication year - 2021
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.14744
Subject(s) - medicine , insulin resistance , endocrinology , oxidative stress , malondialdehyde , insulin , glutathione peroxidase , quantitative insulin sensitivity check index , superoxide dismutase , insulin sensitivity
Abstract Background Over the past few years, the benefits of omega‐3 fatty acids have been reported in the management of non‐alcoholic fatty liver disease (NAFLD) complications.This study evaluated the effects of Camelina sativa oil (CSO) supplementation as one of the richest dietary sources of omega‐3 fatty acids on glucose homeostasis,inflammation, metabolic endotoxemia, and oxidative stress in NAFLD patients. Methods A total of 46 patients with NAFLD were allocated to either an intervention (20 g/d CSO) or placebo (20 g/d sunflower oil) group receiving a calorie‐restricted diet for 12 weeks. Fasting plasma levels of glycemic indices, hs‐CRP, lipopolysaccharide (LPS), antioxidant enzymes activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8‐iso‐prostaglandin F2α (8‐iso‐PGF2α), and uric acid were measured at baseline and post‐intervention. Results The CSO supplementation led to significant differences in insulin concentration, homeostasis model assessment of insulin resistance (HOMA‐IR), hs‐CRP, LPS, TAC, superoxide dismutase (SOD) activity, MDA and 8‐iso‐PGF2α between the two groups at end of the study (ANCOVA, P < .05). Hs‐CRP decreased significantly in both groups (pair‐ t ‐test, P < .05). Insulin concentration, quantitative insulin sensitivity check index, LPS, TAC, SOD, glutathione peroxidase activity, MDA and 8‐iso‐PGF2α changed significantly only in CSO group ( P < .05). Conclusion These findings indicate that CSO may improve glycemia, inflammation, metabolic endotoxemia, and oxidative stress status in patients with NAFLD.