Open AccessStudy of gut microbiome in Egyptian patients with autoimmune thyroid diseases
Author(s) -
ElZawawy Hanaa T.,
Ahmed Shwikar M.,
ElAttar Eman A.,
Ahmed Asmaa A.,
Roshdy Yara S.,
Header Doaa A.
Publication year - 2021
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.14038
Subject(s) - medicine , dysbiosis , faecalibacterium prausnitzii , microbiome , bifidobacterium , bacteroidetes , thyroiditis , trab , gut flora , autoimmune thyroiditis , pathogenesis , lactobacillus , immunology , gastroenterology , thyroid , graves' disease , bacteria , bioinformatics , biology , 16s ribosomal rna , genetics
Background Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are the most prevalent forms of autoimmune thyroid disorders (ATD). A pathogenic link with gut microbial dysbiosis has been described in different autoimmune disorders but not yet fully elucidated in patients with ATD. Aim of the work The present study aimed to elucidate changes in gut microbiome in Egyptian patients with ATD. Patients and Methods The gut bacterial composition of 20 patients with ATD and 30 age, sex, and BMI‐matched healthy subjects as controls was analysed using Quantitative SYBR Green Real‐Time PCR technique targeting 16S rRNA of selected bacterial genera and/or species. Results Compared with controls; the Firmictus/Bacteroidetes ratio (known to be representative for healthy status) was significantly decreased in patients with ATD ( P < .001), without a significant difference between GD and HT patients. Also, the relative abundance of beneficial bacteria associated with the gut barrier and anti‐inflammatory state; A. mucinophilia, Bifidobacterium, Lactobacillus, and F. prausnitzii, were decreased in ATD patients. TRAb in GD patients and anti‐TPO in HT patients showed a significant positive correlation with Bacteroidetes ( P = .001) and ( P = .018), respectively. Conclusion Egyptian patients with ATD show dysbiosis of the gut microbiome that can be related to the pathogenesis of ATD. This hopefully points to the potential therapeutic benefits of manipulating the composition of the gut microbiome in the management or even protection from ATD.