Open AccessThe antioxidant and anti‐inflammatory effects of astaxanthin supplementation on the expression of miR‐146a and miR‐126 in patients with type 2 diabetes mellitus: A randomised, double‐blind, placebo‐controlled clinical trial
Author(s) -
Shokrimashhadi Nafiseh,
Tahmasebi Maryam,
Mohammadiasl Javad,
Zakerkish Mehrnoosh,
Mohammadshahi Majid
Publication year - 2021
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.14022
Subject(s) - medicine , placebo , malondialdehyde , oxidative stress , type 2 diabetes mellitus , pathogenesis , diabetes mellitus , clinical trial , gastroenterology , inflammation , astaxanthin , type 2 diabetes , placebo controlled study , endocrinology , antioxidant , immunology , double blind , pathology , biochemistry , alternative medicine , chemistry , carotenoid
Background The pathogenesis of type 2 diabetes mellitus (T2DM) is associated with chronic oxidative stress and inflammation. It is well known that the expression of some miRNAs such as miRNA‐146a is upregulated in diabetic and hyperglycaemic patients, whereas circulating miRNA‐126 is reduced. Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL‐6) levels, and the expression of miR‐146a and miR‐126 in patients with T2DM. Methods This randomised, double‐blind, placebo‐controlled clinical trial was conducted in 44 patients with T2DM randomly receiving 8 mg/d of oral AST (n = 22) or placebo (n = 22) for 8 weeks. Results We observed that AST supplementation could decrease plasma levels of MDA and IL‐6 ( P < .05) and decrease the expression level of miR‐146a over time (fold change: −1/388) ( P < .05). Conclusion AST supplementation might be beneficial for improving circulating MDA and IL‐6 and the down‐regulation of miR‐146a. However, future investigations are suggested to confirm these results.