Open AccessThe association between serum levels of growth differentiation factor‐15 and rheumatoid arthritis activity
Author(s) -
Esalatmanesh Kamal,
Fayyazi Hamidreza,
Esalatmanesh Roozbeh,
Khabbazi Alireza
Publication year - 2020
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.13564
Subject(s) - medicine , rheumatoid arthritis , association (psychology) , gdf15 , arthritis , immunology , rheumatoid factor , philosophy , epistemology
Background Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Growth differentiation factor‐15 (GDF‐15) acts as an autocrine regulator of macrophage activation. Objective: The aim of this study was to assess serum level of GDF‐15 as a potential biomarker for detecting RA activity. Method A total of 100 female RA patients and 55 age and weight matched healthy control females were enroled. The serum level of GDF‐15 was measured using enzyme‐linked immunosorbent assay. Results Serum levels of GDF‐15 in RA patients with high, moderate, low and no disease activity were 989.0 ± 161.9, 505.6 ± 220.5, 349.2 ± 155.9 and 349.0 ± 144.0 pg/mL, respectively. GDF‐15 with a cut‐off value higher than 705 pg/mL was indicative of high RA activity with sensitivity of 96% and specificity of 92%. Conclusion GDF‐15 serum levels may be used as a biomarker to predict high RA disease activity.