Open AccessIncreased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile
Author(s) -
AlaminosCastillo Miguel Á.,
HoPlagaro Ailec,
GarcíaSerrano Sara,
SantiagoFernandez Concepción,
RodríguezPacheco Francisca,
GarridoSanchez Lourdes,
Rodriguez Cristina,
Valdes Sergio,
Gonzalo Montserrat,
MorenoRuiz Francisco J.,
RodríguezCañete Alberto,
MontielCasado Custodia,
GarciaFuentes Eduardo
Publication year - 2019
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.13315
Subject(s) - paraoxonase , pon1 , medicine , arylesterase , endocrinology , aryldialkylphosphatase , biochemistry , chemistry , genotype , oxidative stress , gene
Abstract Aims The paraoxonase‐1 (PON1) enzyme could play an important role in the anti‐oxidant capacity of high‐density lipoprotein. However, there are no studies which analyse the evolution of the three activities of PON1 (PON arylesterase, PON paraoxonase and PON lactonase) after Roux‐en‐Y Gastric Bypass (RYGB) in morbidly obese subjects. We analysed the association of PON concentration and activities with the evolution of morbidly obese subjects who underwent RYGB, and its relationship with biochemical variables and different atherogenic indices. Methods Twenty‐seven non‐obese and 82 morbidly obese subjects were studied before and 6 months after RYGB. Results Before RYGB, morbidly obese subjects had a lower PON1 concentration ( P < 0.05) and higher PON lactonase activity ( P < 0.001) than non‐obese subjects, with no differences in PON arylesterase and PON paraoxonase activities. After RYGB, PON1 concentration ( P < 0.05) and PON lactonase activity ( P < 0.001) decreased with regard to the presurgery state. PON lactonase activity correlated with the atherogenic index of plasma before ( r = 0.19, P = 0.047) and after RYGB ( r = 0.27, P = 0.035). In different multiple lineal regression analysis models, presurgery PON lactonase activity was associated with total cholesterol (β = 0.909, P < 0.001), LDL (β = 0.632, P = 0.006) and DBP (β = 0.230, P = 0.030) ( R 2 = 0.295), postsurgery PON lactonase activity was associated with esterified cholesterol (β = 0.362, P = 0.011) ( R 2 = 0.131), and the change (Δ) in PON lactonase activity after RYGB was associated with Δesterified cholesterol (β = 0.304, P = 0.030) ( R 2 = 0.093). Conclusions PON lactonase activity is associated with the presence of morbid obesity and with an impaired lipid profile. All associations found could indicate the relationship between PON lactonase activity and the development of atherosclerosis.