Open AccessThe analysis of microbial spectrum and antibiotic resistance of uropathogens isolated from patients with urinary stones
Author(s) -
Chen Dong,
Zhang Yuyan,
Huang Jian,
Liang Xiongfa,
Zeng Tao,
Lan Chuangxin,
Duan Xiaolu,
Zhao Zhijian,
Zeng Guohua,
Tiselius HansGöran,
Lu Xiaogang,
Wu Wenqi
Publication year - 2018
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.13205
Subject(s) - medicine , proteus mirabilis , cefepime , klebsiella pneumoniae , urinary system , enterococcus faecalis , ceftriaxone , ertapenem , antibiotic resistance , microbiology and biotechnology , antimicrobial , ceftazidime , urine , antibiotics , escherichia coli , bacteria , imipenem , staphylococcus aureus , pseudomonas aeruginosa , biology , biochemistry , gene , genetics
Summary Purpose The characteristics and resistance patterns of urine bacteriology in patients with urinary tract stones have not been extensively studied. This study aims to investigate the microbial spectrum and antibiotic resistance of uropathogens isolated from urinary tract infections in patients with urinary stones and provide a basis for appropriate antimicrobial treatments. Methods The results of positive bladder midstream urine cultures and their antimicrobial susceptibility were retrospectively analysed from hospitalised patients with diagnosis of urinary calculi and urinary tract infections between January 2010 and December 2015. Results A total of 3892 samples were analysed during the study period: 2201 were female patients (56.6%) and 1691 were male patients (43.4%). The 4 most common uropathogens were Escherichia coli (48.7%), Klebsiella pneumoniae (10.4%), Enterococcus faecalis (8.7%) and Proteus mirabilis (5.2%). Both E. coli (60.8%) and Proteus mirabilis (7.5%) were higher in female patients than in male patients (32.8%; 2.3%; P < .05). ESBL ‐positive E. coli accounted for 59.5% of total number of E. coli , w hile ESBL ‐positive K. pneumoniae comprised 42.0% of total K. pneumoniae . The majority of uropathogens in patients with stones had high resistance to fluoroquinolones, ceftriaxone, ceftazidime, cefepime, penicillins, sulfonamides and monobactams (resistance >20%). Conclusions The microbial spectrum in patients with urinary stones had a complex pattern. The uropathogens showed marked multidrug resistance and a large proportion of the uropathogens were able to produce β‐lactamase.