Open AccessComparison of the impact of human vs analogue insulins on glycosylated haemoglobin in a population with diabetes mellitus
Author(s) -
MachadoAlba Jorge Enrique,
MedinaMorales Diego Alejandro
Publication year - 2016
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/ijcp.12904
Subject(s) - medicine , nph insulin , diabetes mellitus , metabolic control analysis , insulin glargine , insulin , type 2 diabetes mellitus , human insulin , cohort , population , endocrinology , type 2 diabetes , environmental health
Summary Aims To compare the effect on metabolic control of treatment with conventional and analogue insulins for patients with diabetes mellitus. Methods Retrospective cohort study held in cities of Colombia (Pereira and Manizales). People insured by the paid healthcare system, who were diagnosed with diabetes mellitus type 1 and 2, and treated with conventional and analogue insulin for at least 6 months prior to the start of the study were sampled and followed up for 18 months. Data were collected from clinical records for each patient. Treatment groups were compared according to the type of insulin received. Results A total of 313 patients were included; overall, 56.9% were women and the mean age was 57.3 years. No statistically significant difference was found in glycosylated haemoglobin reduction at 3, 6 and 18 months when comparing patients receiving glargine vs NPH insulin ( P =.403) and NPH plus zinc crystalline insulin vs glargine plus glulisine ( P =.514). The percentage of patients with metabolic control increased from 27.8% to 34.2% during follow‐up with all types of insulin. Conclusions Insulin analogues were not superior to human insulin for glycaemic control. A significant proportion of patients did not attain the treatment goals; therefore, it is necessary to implement measures to improve the monitoring and control of diabetes mellitus.