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Phosphate content affects structure and bioactivity of sol‐gel silicate bioactive glasses
Author(s) -
Ting HungKai,
Page Sam J.,
Poologasundarampillai Gowsihan,
Chen Shu,
Yu Bobo,
Hanna John V.,
Jones Julian R.
Publication year - 2017
Publication title -
international journal of applied glass science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 34
eISSN - 2041-1294
pISSN - 2041-1286
DOI - 10.1111/ijag.12322
Subject(s) - simulated body fluid , phosphate , apatite , materials science , chemical engineering , polyphosphate , sol gel , calcium , bioactive glass , mineralogy , silicate , phosphate glass , nuclear chemistry , chemistry , organic chemistry , composite material , nanotechnology , metallurgy , engineering
Bioactive glasses can heal bone defects and bond with bone through formation of hydroxyl carbonate apatite (HCA) surface layer. Sol‐gel derived bioactive glasses are thought to have potential for improving bone regeneration rates over melt‐derived compositions. The 58S sol‐gel composition (60 mol% SiO 2 , 36 mol% CaO, and 4 mol% P 2 O 5 ) has appeared in commercial products. Here, hydroxyapatite (HA) was found to form within the 58S glass during sol‐gel synthesis after thermal stabilization. The preformed HA may lead to rapid release of calcium orthophosphate, or nanocrystals of HA, on exposure to body fluid, rather than the release of separate the calcium and phosphate species. Increasing the P 2 O 5 to CaO ratio in the glass composition reduced preformed HA formation, as observed by XRD and solid‐state NMR. Instead, above 12 mol% phosphate, a phosphate glass network (polyphosphate) formed, creating co‐networks of phosphate and silica. Nanopore diameter of the glass and rate of HCA layer formation in simulated body fluid (SBF) decreased when the phosphate content increased.