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Synthesizing the strontium carbonate and silver doped bioceramic bone graft: Structure‐properties and cell viability
Author(s) -
Demirel Mehtap,
Kaya Ali İ.,
Aksakal Bünyamin
Publication year - 2019
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/ijac.13316
Subject(s) - bioceramic , materials science , scanning electron microscope , fourier transform infrared spectroscopy , sintering , strontium , nuclear chemistry , strontium carbonate , mineralogy , chemical engineering , viability assay , composite material , chemistry , organic chemistry , biochemistry , engineering , cell
An alternative bioceramic bone graft was synthesized through the sol‐gel method by substituting strontium carbonate—SrCO 3 and Silver—Ag into Ca(NO 3 ) 2 ·4H 2 O, KOH, NaNO 3 , P 2 O 5 , and urea compounds. Morphological properties of the fabricated grafts were characterized by X‐ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Mechanical properties were determined via the hardness and compression tests. Furthermore, the cell viability of fabricated biografts was also determined via cytotoxicity tests using the MTS (cell proliferation assay). FTIR, EDS, and XRD analyses indicated that SrCO 3 ‐ and Ag‐substituted hydroxyapatite (Sr/Ag/HA) biograft fabrications were achieved. SEM images of the biografts showed that a low‐porous structure was formed with grains bonded through sintering. SEM images also revealed that the powder bonding increased due to the decrease in pore sizes when the amount of SrCO 3 was increased. From the mechanical tests, it was obtained that, the strength and hardness increased with increased SrCO 3 rates. Through the cytotoxicity tests, it was shown that the cell viability rate increased due to the presence of SrCO 3 and no toxic effects were observed through the newly synthesized biografts.