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Synthesis of mesoporous magnesium phosphates as dispersing carriers for cryptotanshinone solid dispersions
Author(s) -
Zhou Huan,
Bi Yaping,
Yang Mengmeng,
Wang Wenjie,
Ni Xinye,
Xu Defeng
Publication year - 2018
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/ijac.12859
Subject(s) - dissolution , mesoporous material , solubility , chemical engineering , materials science , amorphous solid , solvent , agglomerate , nanoparticle , dispersant , inorganic chemistry , nuclear chemistry , chemistry , nanotechnology , organic chemistry , dispersion (optics) , catalysis , engineering , physics , optics
In current work, solid dispersions (SDs) of Cryptotanshinone (CPT) using mesoporous magnesium phosphates (MgPs) as the dispersing carrier (CPT‐MgPs SDs) were prepared, characterized, and evaluated. Three mesoporous MgPs (MgP, MgP‐Vc, and MgP‐Triton) with different phases and morphology were hydrothermally synthesized first. After that, they were combined with CPT to prepare SDs by an ethanol‐based solvent evaporation method. It was observed that the large CPT crystals were transformed into amorphous micro‐molecular particles and well dispersed in MgPs nanoparticles after the solvent evaporation procedure. In addition, all MgPs were self‐assembled into microspherical agglomerates of palate‐like particles. The dissolution studies of CPT from MgPs indicated that 1) the dissolution of CPT from SDs can be improved on comparison to pure CPT, 2) MgP is the best among all carrier tested, but still not satisfactory. In addition, 2 other phenomena about CPT‐MgP SD were observed. One was that an apparent increasing trend is seen between the MgP weight ratios and the dissolution rate of CPT. The other one was that MgP can be a pH responsive carrier to tailor the dissolution behavior of CPT. Development of promising SD with CPT solubility improvement, pH responsibility, and sustained drug release ability is still deserved in future.