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In vitro self‐setting properties, bioactivity, and antibacterial ability of a silicate‐based premixed bone cement
Author(s) -
Xu Chen,
Wen Yang,
Zhou Yanling,
Zhu Yaqin,
Dou Yuandong,
Huan Zhiguang,
Chang Jiang
Publication year - 2017
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/ijac.12813
Subject(s) - materials science , cement , silicate , chemical engineering , mixing (physics) , dental cement , bone cement , apatite , polyethylene glycol , calcium silicate , ethylene glycol , calcium , composite material , dentistry , metallurgy , medicine , physics , adhesive , layer (electronics) , quantum mechanics , engineering
The clinical use of cements in root canal treatment needs the dentist to mix the powders and liquid phase thoroughly. The operation not only increases the surgery time but also compromises the performance of cement in case of inhomogeneous or insufficient mixing. To overcome those drawbacks, a premixed tricalcium silicate cement (C 3 S) was prepared by mixing tricalcium silicate/calcium chloride (C 3 S/CaCl 2 ) composites with polyethylene glycol ( PEG ). It was found that the setting time could be modulated by changing the content of CaCl 2 in the solid phase and the liquid to solid ratio (L/P). In addition, the premixed pastes retained the bioactivity of C 3 S, such as the ability to induce apatite formation in simulated oral fluid and to promote the proliferation and the alkaline phosphate ( ALP ) activity of human dental pulp stem cells ( hDPSC s). Meanwhile, the injected pastes showed good antibacterial ability against Staphylococcus aureus. It is thus expected that the premixed C 3 S/CaCl 2 pastes hold great promise as a new type of materials for dental application.