Sintering behavior and biocompatibility of a low temperature co‐fired ceramic for microfluidic biosensors | Zendy

Luo Jin | Zendy; Eitel Richard | Zendy

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Sintering behavior and biocompatibility of a low temperature co‐fired ceramic for microfluidic biosensors

Author(s) -

Luo Jin,

Eitel Richard

Publication year - 2017

Publication title -

international journal of applied ceramic technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 57

eISSN - 1744-7402

pISSN - 1546-542X

DOI - 10.1111/ijac.12648

Subject(s) - materials science , sintering , biocompatibility , ceramic , microfluidics , biosensor , umbilical vein , composite material , biomedical engineering , nanotechnology , chemical engineering , in vitro , metallurgy , chemistry , medicine , biochemistry , engineering

A low temperature co‐fired ceramic ( LTCC ) has been formulated and evaluated for in‐vitro microfluidic sensors and cell culture applications. Using a 75/25 vol% glass to alumina ratio, high density was achieved for sintering temperatures <900°C. No toxicity was observed in the leachate medium obtained by soaking LTCC in cell medium for 5 days. The human umbilical vein endothelial cells ( HUVEC s) also attached on the fibronectin‐coated LTCC after 14 hours and proliferated after 74 hours. On the basis of these results, the current LTCC formulation is a viable candidate for the continued development of LTCC ‐based microfluidic biosensors.

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