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Sintering behavior and biocompatibility of a low temperature co‐fired ceramic for microfluidic biosensors
Author(s) -
Luo Jin,
Eitel Richard
Publication year - 2017
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/ijac.12648
Subject(s) - materials science , sintering , biocompatibility , ceramic , microfluidics , biosensor , umbilical vein , composite material , biomedical engineering , nanotechnology , chemical engineering , in vitro , metallurgy , chemistry , medicine , biochemistry , engineering
A low temperature co‐fired ceramic ( LTCC ) has been formulated and evaluated for in‐vitro microfluidic sensors and cell culture applications. Using a 75/25 vol% glass to alumina ratio, high density was achieved for sintering temperatures <900°C. No toxicity was observed in the leachate medium obtained by soaking LTCC in cell medium for 5 days. The human umbilical vein endothelial cells ( HUVEC s) also attached on the fibronectin‐coated LTCC after 14 hours and proliferated after 74 hours. On the basis of these results, the current LTCC formulation is a viable candidate for the continued development of LTCC ‐based microfluidic biosensors.