Premium
Loading and Delivery of Anticancer Drugs using Montmorillonite
Author(s) -
Betsiou Maria,
Bantsis Georgios,
Sikalidis Costas,
Zoi Ioanna,
Bourliva Anna
Publication year - 2013
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/ijac.12095
Subject(s) - montmorillonite , adsorption , materials science , drug delivery , kinetics , nuclear chemistry , chemical engineering , nanotechnology , chemistry , organic chemistry , composite material , engineering , physics , quantum mechanics
This study aimed to investigate in vitro the montmorillonite ( MMT ) as carrier for gemcitabine hydrochloride (d F d U . HC l) and oxaliplatin ( DACH ‐ P t). The maximum adsorption capacities of MMT and their respective mechanisms were determined through a soaking procedure (387.5 mg d F d U . HC l/g MMT were adsorbed in 32 h, 83 mg DACH ‐ P t/g MMT in 48 h). Release kinetics studies were carried out soaking the samples of loaded MMT in simulated body fluids ( SBF ). Finally, in an attempt to explain the mechanism of drug delivery, the chemical interactions were studied theoretically, according to the adsorption and release profiles.