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CARLo‐7 —A plausible biomarker for bladder cancer
Author(s) -
Amir Hina,
Khan Mohammad Azam,
Feroz Saima,
Bibi Nazia,
Nawaz Muhammad,
Mehmood Arshad,
Yousuf Arzu,
Khawaja Mohammad Athar,
Khadim Muhammad Tahir,
Tariq Aamira
Publication year - 2019
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12305
Subject(s) - rna , biology , bladder cancer , gene expression , cancer research , cancer , gene , oncogene , long non coding rna , regulation of gene expression , genetics , cell cycle
Summary Cancer is defined as undifferentiated and unchecked growth of cells damaging the surrounding tissue. Cancers manifest altered gene expression. Gene expression is regulated by a diverse array of non‐protein‐coding RNA . Aberrant expression of long non‐coding RNA s (lnc RNA s) has been recently found to have functional consequences in cancers. In the current study, we report CARL o‐ 7 as the only bladder cancer–specific lnc RNA from the CARL os cluster. The expression of this lnc RNA correlates with bladder cancer grade. We propose that CARL o‐7 has an oncogenic potential and might be regulator of cell proliferation. Furthermore, by comparison the expression of proto‐oncogene MYC , which is the only well‐annotated gene close to the cancer ‐ associated linkage disequilibrium blocks of this region, does not show a pronounced change in expression between the low‐ and high‐grade tumours. Our results indicate that CAR lo‐7 can act as a prognostic marker for bladder cancer.