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Association of miR‐1247‐5p expression with clinicopathological parameters and prognosis in breast cancer
Author(s) -
Zhang Peng,
Fan Changsheng,
Du Jun,
Mo Xueli,
Zhao Qikang
Publication year - 2018
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12287
Subject(s) - breast cancer , reverse transcriptase , pathological , cancer research , microrna , oncology , biomarker , stage (stratigraphy) , lymph node , real time polymerase chain reaction , breast carcinoma , pathology , medicine , cancer , polymerase chain reaction , biology , gene , paleontology , biochemistry
Summary Our study aimed to clarify the correlation between miR‐1247‐5p expression and clinicopathological parameters and survival of patients with breast cancer ( BC ). We evaluated the expression level of miR‐1247‐5p in 224 formalin‐fixed, paraffin‐embedded specimens (112 BC and matched cancer free tissues) by quantitative real‐time reverse transcriptase polymerase chain reaction ( qRT ‐ PCR ). miR‐1247‐5p expression in BC tissues was found to be decreased compared with matched normal tissues ( P < 0.01). Additionally, low miR‐1247‐5p expression in BC tissues was significantly associated with the advanced TNM stage ( P = 0.007), lymph node metastasis ( P = 0.015), poorer pathological differentiation ( P = 0.005) and molecular subtype ( P = 0.027). The patients in the low miR‐1247‐5p group had a shorter disease‐free survival and overall survival than those in the high miR‐1247‐5p group ( P < 0.01). Furthermore, the univariate and the multivariate analyses showed that miR‐1247‐5p expression was an independent predictor of overall survival ( P < 0.01). Our study showed that miR‐1247‐5p was related to the biological behaviour of breast tumour and prognosis of patients with BC. miR‐1247‐5p could be a novel tumour suppressor and act as a potential biomarker and therapeutic agent for breast carcinoma.