British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell‐extracellular matrix communication | Zendy

Ismail, HM | Zendy; Yamamoto, K | Zendy; Nagase, H | Zendy; Vincent, TL | Zendy; Troeberg, L | Zendy; Saklatvala, J | Zendy

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British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell‐extracellular matrix communication

Author(s) -

Ismail, HM,

Yamamoto, K,

Nagase, H,

Vincent, TL,

Troeberg, L,

Saklatvala, J

Publication year - 2017

Publication title -

international journal of experimental pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.671

H-Index - 72

eISSN - 1365-2613

pISSN - 0959-9673

DOI - 10.1111/iep.12235

Subject(s) - extracellular matrix , matrix (chemical analysis) , spring (device) , biology , microbiology and biotechnology , chemistry , physics , chromatography , thermodynamics

The JNK pathway (c-jun N-terminal kinase) is activated by a variety of inflammatory and physical stressful stimuli. Recently, we identified a new and an important role for the JNK pathway in the turnover of the cartilage proteoglycan aggrecan. Loss of JNK2 isoform in human chondrocytes and murine cartilage abolished IL1- induced aggrecan degradation and aggrecanase activity. Furthermore, JNK2-null mice were protected from surgically-induced osteoarthritis. Here we show that the JNK2-dependent effect on the aggrecan degradation is linked to an LRP1-dependent endocytic mechanism

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