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British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell‐extracellular matrix communication
Author(s) -
Ismail, HM,
Yamamoto, K,
Nagase, H,
Vincent, TL,
Troeberg, L,
Saklatvala, J
Publication year - 2017
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12235
Subject(s) - extracellular matrix , matrix (chemical analysis) , spring (device) , biology , microbiology and biotechnology , chemistry , physics , chromatography , thermodynamics
The JNK pathway (c-jun N-terminal kinase) is activated by a variety of inflammatory and physical stressful stimuli. Recently, we identified a new and an important role for the JNK pathway in the turnover of the cartilage proteoglycan aggrecan. Loss of JNK2 isoform in human chondrocytes and murine cartilage abolished IL1- induced aggrecan degradation and aggrecanase activity. Furthermore, JNK2-null mice were protected from surgically-induced osteoarthritis. Here we show that the JNK2-dependent effect on the aggrecan degradation is linked to an LRP1-dependent endocytic mechanism