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A 12‐month follow‐up study on the preventive effect of oral lansoprazole on acute exacerbation of chronic obstructive pulmonary disease
Author(s) -
Xiong Wei,
Zhang Quansan,
Zhao Wei,
Ding Wei,
Liu Jinming,
Zhao Yunfeng
Publication year - 2016
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12173
Subject(s) - lansoprazole , medicine , exacerbation , gastroenterology , copd , sputum , pulmonary function testing , group b , pathology , helicobacter pylori , tuberculosis
Summary The objective of this study was to evaluate the preventive effects of oral administration of lansoprazole on acute exacerbation of chronic obstructive pulmonary disease ( COPD ). Patients with COPD in groups C and D in the stable phase were stratified into a group with neither gastroesophageal reflux nor lansoprazole therapy (group A) and a group subjected to oral lansoprazole therapy (group B 1 ) and a group not subjected to oral lansoprazole therapy (group B 2 ). The frequency scale for the symptoms of gastroesophageal reflux disease ( FSSG ) questionnaire, COPD assessment test (CAT) questionnaire, pulmonary function test and the 6‐minute walk test were applied; in addition, arterial blood gas, white blood cell ( WBC ), hs‐ CRP , liver function and the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in sputum were monitored during follow‐up. In the 12‐month follow‐up period, the frequency of exacerbation in group B 2 was statistically higher than that in groups A and B 1 ( P < 0.05). After a 3‐month follow‐up, the score of groups A and B 1 in the FSSG questionnaire was significantly lower than that of group B 2 ( P < 0.05). After the 1‐year follow‐up, the CAT score, FEV 1 , 6‐min walk test, the total number of WBC , hs‐ CRP , alanine aminotransferase, aspartate aminotransferase, pH of the arterial blood, PaO 2 , Pa CO 2 and the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in the sputum were statistically different in group B 2 compared with groups A and B 1 ( P < 0.05). Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in the sputum.