Premium Diabetes increases pancreatitis induced systemic inflammation but has little effect on inflammation and cell death in the lungPremium
Author(s)
Zechner Dietmar,
Spitzner Marie,
MüllerGraff Tassilo,
Vollmar Brigitte
Publication year2014
Publication title
international journal of experimental pathology
Resource typeJournals
Summary Acute pancreatitis ( AP ) can lead to a systemic inflammatory response that often results in acute lung injury and single or multiple organ failure. In a previous study we demonstrated that diabetes aggravates the local pathophysiological process during AP . In this study we explore, if diabetes also increases pancreatitis induced systemic inflammation and causes lung injury. Acute pancreatitis was induced in untreated and streptozotocin‐treated diabetic mice by injection of cerulein. Systemic inflammation was studied by IL ‐6 ELISA in blood plasma and white blood cell count. Lung inflammation and lung injury were quantified by chloroacetate esterase staining, evaluation of the alveolar cellularity index and cleaved caspase‐3 immunohistochemistry. In normoglycaemic mice AP increased the IL ‐6 concentration in plasma and caused lymphocytopenia. Diabetes significantly increased the IL ‐6 concentration in plasma and further reduced the number of lymphocytes during AP , whereas diabetes had little effect on these parameters in the absence of pancreatitis. However, diabetes only marginally increased lung inflammation and did not lead to cell death of the lung epithelium during AP . We conclude that diabetes increases parameters of systemic inflammation during AP , but that this increase is insufficient to cause lung injury.
Subject(s)acute pancreatitis , diabetes mellitus , endocrinology , inflammation , lung , medicine , pancreatitis , systemic inflammation , white blood cell
Language(s)English
SCImago Journal Rank0.671
H-Index72
eISSN1365-2613
pISSN0959-9673
DOI10.1111/iep.12103
Seeing content that should not be on Zendy? Contact us.