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The role of the non‐collagenous matrix in tendon function
Author(s) -
Thorpe Chavaunne T.,
Birch Helen L.,
Clegg Peter D.,
Screen Hazel R.C.
Publication year - 2013
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/iep.12027
Subject(s) - tendon , function (biology) , matrix (chemical analysis) , anatomy , medicine , materials science , biology , microbiology and biotechnology , composite material
Summary Tendon consists of highly ordered type I collagen molecules that are grouped together to form subunits of increasing diameter. At each hierarchical level, the type I collagen is interspersed with a predominantly non‐collagenous matrix ( NCM ) ( C onnect. Tissue Res ., 6 , 1978, 11). Whilst many studies have investigated the structure, organization and function of the collagenous matrix within tendon, relatively few have studied the non‐collagenous components. However, there is a growing body of research suggesting the NCM plays an important role within tendon; adaptations to this matrix may confer the specific properties required by tendons with different functions. Furthermore, age‐related alterations to non‐collagenous proteins have been identified, which may affect tendon resistance to injury. This review focuses on the NCM within the tensional region of developing and mature tendon, discussing the current knowledge and identifying areas that require further study to fully understand structure–function relationships within tendon. This information will aid in the development of appropriate techniques for tendon injury prevention and treatment.