Premium
Association between cardiovascular diseases and apical periodontitis: an umbrella review
Author(s) -
Jakovljevic A.,
Duncan H. F.,
Nagendrababu V.,
Jacimovic J.,
Milasin J.,
Dummer P. M. H.
Publication year - 2020
Publication title -
international endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.988
H-Index - 119
eISSN - 1365-2591
pISSN - 0143-2885
DOI - 10.1111/iej.13364
Subject(s) - systematic review , medicine , cochrane library , medline , meta analysis , scopus , data extraction , protocol (science) , web of science , periodontitis , categorization , alternative medicine , pathology , computer science , political science , law , artificial intelligence
Background The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive. Objective To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults. Methods The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics’ Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta‐analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of ‘high’, ‘moderate’, ‘low’ or ‘critically low’ quality. Results Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as ‘moderate’ quality, whereas one review was graded as ‘critically low’ quality. Discussion Only one systematic review included a meta‐analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis. Conclusions From the limited ‘moderate’ to ‘critically low’ quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well‐designed, longitudinal clinical studies with long‐term follow‐up are required.